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The Effect of EnfIurane, lsofIurane, FIuroxene, Methoxyflurane and Diethyl Ether Anesthesia on Ouabain Tolerance in the Dog

ANTHONY D. IVANKOVICH, MD^*, DAVID J. MILETICH, PhD, RONALD K. GROSSMAN, MD, RONALD F. ALBRECHT, MD, ADEL A. EL-ETR, MD^||, and VINCENT J. CAIROLI, PhD^**

*Chairman. Department of Anesthesiology. Illinois Masonic Medical Center, Professor of Anesthesiology, University of Illinois, Abraham Lincoln School of Medicine, Chicago, Illinois. dagger;Director of Anesthesia Research. Michael Reese Medical Center, Chicago, Illinois. Clinical Assistant Professor of Anesthesiology, University of Illinois, Abraham Lincoln School of Medicine. Chicago, Illinois. Chairman. Department of Anesthesiology, Michael Reese Medical Center, Professor of Anesthesiology, University of Chicago, Pritzker School of Medicine, Chicago. Illinois. ||Professor and Chairman. Department of Anesthesiology. Loyola University. Stritch School of Medicine, Maywood. Illinois. **Director of Anesthesia Research, Illinois Masonic Medical Center, Chicago, Illinois.

Abstract

Digitalis tolerance in dogs anesthetized with enflurane, isoflurane, fluroxene, methoxyflurane, and diethyl ether was compared with that in dogs anesthetized with pentobarbital. Ouabain dosage needed to cause ventricular tachycardia was significantly higher than that of pentobarbital with all agents except fluroxene, as was the LD₃₀ The relative potency of these anesthetics in converting ouabain-induced ventricular tachycardia to sinus rhythm, in order of descending effectiveness, was: diethyl ether, methoxyflurane, enflurane, fluroxene, isoflurane, pentobarbital.