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Anesth Analg 1980; 59:263-269
© 1980 International Anesthesia Research Society
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Noninvasive Measurement of Pulmonary Gas Exchange during General Anesthesia

Frances E. Noe, MD*, Albert J. Whitty, PhD{dagger}, Kenneth R. Davies, BA{ddagger}, and Barbara L. Wickham, BS§

*Attending Staff, Sinai Hospital; Assistant Professor, Department of Anesthesiology, Wayne State University. Departments of Anesthesiology and Research, Sinai Hospital of Detroit, Detroit, Michigan 48235. {dagger}Acting Chairman, Department of Research, Sinai Hospital; Associate Professor, Department of Physiology, Wayne State University. Departments of Anesthesiology and Research, Sinai Hospital of Detroit, Detroit, Michigan 48235. {ddagger}Research Fellow, Sinai Hospital. Departments of Anesthesiology and Research, Sinai Hospital of Detroit, Detroit, Michigan 48235. §Staff Research Associate, Sinai Hospital. Departments of Anesthesiology and Research, Sinai Hospital of Detroit, Detroit, Michigan 48235.

Abstract

Expired gas flow volume (VE), carbon dioxide excretion (Vco2) and oxygen consumption (Vo2) were measured continuously for 2-minute periods at 15-minute intervals during at least 75 minutes of general anesthesia and surgery in clinical patients. Analog tape-recorded outputs from an infrared CO2 analyzer, from a rapid polarographic O2 analyzer, and from a pneumo-tachograph were subsequently processed by a general purpose digital computer. Values for VE, VCO2, and VO2 in a group of 50 normal paralyzed endotracheally intubated women with balanced N2O-O2-fentanyl anesthesia for lower abdominal surgery compare favorably with the few published reports of similar measurements. The measured response to anesthesia and surgery in most patients included a progressive increase in O2 uptake and a concurrent but not necessarily simultaneous decrease in CO2 output with a consequent decreased respiratory gas exchange ratio (RE).

Key Words: MEASUREMENT TECHNIQUES: pulmonary gas exchange • CARBON DIOXIDE: output • OXYGEN: uptake.







Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1980 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1980 by the International Anesthesia Research Society.