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Reduction of Enflurane-Induced Spike Activity by Scopolamine

S. S. Moorthy, MD^*, R. V. Reddy, MD, Raymond R. Paradise, PhD, Alvin M. Losasso, MD, and Philip S. Gibbs, MD^*

*Assistant Professor, Department of Anesthesiology Indiana University School of Medicine, 1100 West Michigan Street, Indianapolis, Indiana 46223. Assistant Professor, Department of Neurology, Indiana University School of Medicine, 1100 West Michigan Street, Indianapolis, Indiana 46223. Professor, Departments of Anesthesiology and Pharmacology, Indiana University School of Medicine, 1100 West Michigan Street, Indianapolis, Indiana 46223. Professor, Department of Anesthesiology Indiana University School of Medicine, 1100 West Michigan Street, Indianapolis, Indiana 46223.

Abstract

The possibility of enflurane-induced spike activity being related to a cholinergic mechanism was investigated. Thirty mongrel dogs were anesthetized with an inspired enflurane concentration of 3.5 ± 0.09% (mean ± SD) to obtain a sustained EEG spike activity. Scopolamine, in 0.04 mg/kg to 0.4 mg/kg IV doses, significantly decreased the spike activity (p < 0.05). We speculate that a central cholinergic muscarinic mechanism is at least partly responsible for the EEG spike activity produced by enflurane.

Key Words: ANESTHETICS, Intravenous: enflurane • BRAIN: electroencephalography • PARASYMPATHETIC NERVOUS SYSTEM: scopolamine • ACETYLCHOLINE: brain.