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Anesth Analg 1980; 59:421-425
© 1980 International Anesthesia Research Society
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Developmental Toxicity of Methoxyflurane in Mice

Robert S. Wharton, MD*, Timothy S. Sievenpiper, MD{dagger}, and Richard I. Mazze, MD{ddagger}

*Assistant Professor of Anesthesiology, The Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, and the Veterans Administration Medical Center, 3801 Miranda Avenue, Palo Alto, California 94304. {dagger}Assistant Professor of Anesthesiology, State University of New York, Buffalo, New York. {ddagger}Professor of Anesthesiology, The Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, and the Veterans Administration Medical Center, 3801 Miranda Avenue, Palo Alto, California 94304.

Abstract

The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring.

Key Words: ANESTHETICS, Volatile: methoxyflurane • PREGNANCY: fetal development • TOXICITY: methoxyflurane.
Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1980 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1980 by the International Anesthesia Research Society.