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Effect of Halothane, Enflurane, and Nitrous Oxide on Tracheal Ciliary Activity in Vitro

Kyu Sun Lee, MD^*, and Sung Suh Park, MD

*Instructor in Anesthesiology, Albert Einstein College of Medicine; Attending Anesthesiologist, Pelham Bay General Hospital, Bronx, New York. Associate Professor of Medicine, Albert Einstein College of Medicine.

Abstract

Effects of halothane, enflurane, and nitrous oxide on ciliary beats were evaluated using a photoelectric system in dissected rabbit tracheal segments. Dose-dependent suppression of the frequency of ciliary beats of moderate degrees was observed after exposure of tracheal segments to warmed and humidified vapors of halothane and enflurane. No suppression, however, was noted after exposure to nitrous oxide. These findings suggest that halothane and enflurane directly suppress ciliary activity.

Key Words: LUNG: tracheal cilia • ANESTHETICS, Volatile: halothane • ANESTHETICS, Volatile: enflurane • ANESTHETICS, Gases: nitrous oxide.

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