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Anesth Analg 1981; 60:508-512
© 1981 International Anesthesia Research Society
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Relationship between Arterial and Peak Expired Carbon Dioxide Pressure during Anesthesia and Factors Influencing the Difference

Robert Whitesell, MD*, Caridad Asiddao, MD*, Daniel Gollman, MD{dagger}, and James Jablonski, BS{ddagger}

*Assistant Professor, Department of Anesthesia, Medical College of Wisconsin, 8700 West Wisconsin Avenue, Milwaukee, Wisconsin 53226. {dagger}Anesthesia Resident, Department of Anesthesia, Medical College of Wisconsin, 8700 West Wisconsin Avenue, Milwaukee, Wisconsin 53226. {ddagger}Clinical Engineer, Department of Anesthesia, Medical College of Wisconsin, 8700 West Wisconsin Avenue, Milwaukee, Wisconsin 53226.

Abstract

To determine how closely peak expired PCO2 measured by mass spectrometry reflects arterial PCO2 during anesthesia and what variables contribute to a difference between the two measurements, peak expired CO2, arterial PCO2, and other physiologic variables were measured simultaneously. There was a significant correlation between peak expired and arterial PCO2 (P < 0.001). The difference between temperature-corrected arterial and peak expired PCO2 was related to the presence or absence of lung disease, age, A.S.A. class, and systolic blood pressure. No significant relationship was seen between the temperature-corrected difference and duration of anesthesia, diastolic pressure, expired O2 concentration, or anesthetic agent. Mean temperature-corrected arterial PCO2 exceeded mean peak expired PCO2 by 1.7 torr in all patients, 0.8 torr in patients without lung disease, and 3.3 torr in patients with lung disease. In patients in whom more than one arterial sample was obtained, initial differences correlated significantly with subsequent differences (p < 0.001).

Key Words: CARBON DIOXIDE: arterial-alveolar gradients




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1981 by the International Anesthesia Research Society.