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Anesth Analg 1981; 60:513-516
© 1981 International Anesthesia Research Society
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Deliberate Hypotension and Anesthetic Requirements of Halothane

Tadikonda L. K. Rao, MD*, Kurt Jacobs, PhD{dagger}, M. R. Salem, MD{ddagger}, and P. Santos, MD§

*Assistant Professor, Department of Anesthesiology, Loyola University Stritch School of Medicine, Maywood, Illinois {dagger}Assistant Professor, Department of Surgery and Physiology, Loyola University Stritch School of Medicine, Maywood, Illinois {ddagger}Professor, Department of Anesthesiology, Loyola University Stritch School of Medicine, Maywood, Illinois §Attending Physician, Department of Anesthesiology, Cook County Hospital, Chicago, Illinois.

Abstract

Following determination of minimum alveolar anesthetic concentration (MAC) of halothane during normotension, 18 dogs were divided into three groups. Dogs in each group then received either pentolinium, trimethaphan, or sodium nitroprusside, and mean arterial pressure was decreased to 60% of control values for 1 hour. The MAC of halothane was determined during hypotension and then arterial pressure was returned to control values and MAC was redetermined at normotension. The MAC of halothane decreased significantly during hypotension in all three groups: in the pentolinium group from a control MAC of 1.2 ± 0.14 (SEM) to a MAC of 0.7 ± 0.11 during hypotension, in the trimethaphan group from a control MAC of 1.02 ± 0.06 to a MAC of 0.72 ± 0.07 during hypotension, and in the nitroprusside group from a control MAC of 1.02 ± 0.07 to a MAC of 0.73 ± 0.07 during hypotension. Upon return of mean arterial pressure to normotensive levels, MAC of halothane returned to control values in dogs given pentolinium and trimethaphan, but in dogs given nitroprusside MAC remained at the hypotensive value. There was no correlation between the changes in MAC and carotid blood flow or cardiac index. These data indicate that anesthetic requirements decrease during deliberate hypotension irrespective of the drug used to produce hypotension.

Key Words: ANESTHETIC TECHNIQUES: hypotensive • POTENCY, Anesthetic: MAC




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1981 by the International Anesthesia Research Society.