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Anesth Analg 1981; 60:548-551
© 1981 International Anesthesia Research Society
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Does Evidence of Reductive Halothane Biotransformation Correlate Halothane with Hepatic Binding of Metabolites in Obese Patients?

John B. Bentley, MD*, Robert W. Vaughan, MD{dagger}, Randall C. Cork, MD, PhD*, and A. Jay Gandolfi, PhD{ddagger}

*Assistant Professor. {dagger}Associate Professor. {ddagger}Research Associate. Received from the Department of Anesthesiology, Arizona Health Sciences Center, Tucson, Arizona 85724.

Abstract

Covalent binding of fluorinated anesthetic metabolites was measured using intraoperative liver biopsies obtained from 48 morbidly obese patients randomly assigned to receive N2O-O2 combined with either tentanyl, enflurane, or halothane. No difference in binding was found between anesthetic groups. In addition, preoperative and postoperative levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) did not differ among three groups of patients. However, hepatic organic fluoride binding significantly correlated with peak serum ionic fluoride in patients given halothane (p < 0.001, r = 0.68). Thus, the fluorinated metabolites binding assay is a reliable index of reductive halothane metabolism. Possible application of this assay to aid in the diagnosis of postoperative liver dysfunction is suggested.

Key Words: BIOTRANSFORMATION (DRUG): fluorometabolites • COMPLICATIONS: obesity • ANESTHETICS, Volatile, halothane, enflurane • ANESTHETICS, Intravenous: tentanyl.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1981 by the International Anesthesia Research Society.