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Anesth Analg 1981; 60:569-573
© 1981 International Anesthesia Research Society
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Propranolol Alters Renin Release during Nitroprusside-Induced Hypotension and Prevents Hypertension on Discontinuation of Nitroprusside

Hoshang J. Khambatta, MD*, J. Gilbert Stone, MD{dagger}, and Emaduddin Khan, MSc{ddagger}

*Assistant Professor. {dagger}Associate Professor. {dagger}Research Worker. Received from the Department of Anesthesiology, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032.

Abstract

Ten patients who received hypotensive anesthesia for surgical correction of a cerebral aneurysm were pretreated for 1 day with propranolol. In the awake state, before start of anesthesia, mean arterial pressure was 91 ± 3 torr and plasma renin activity 3.0 ± 0.1 ng/ml/hr. Thirty minutes after the induction of anesthesia mean arterial pressure decreased to 79 ± 2 torr and plasma renin activity increased to 3.5 ± 0.1 ng/ml/hr. There was no further significant change in either measurement with surgical stimulation. During sodium nitroprusside-induced hypotension (the dose used was 0.35 ± 0.02 mg/kg) mean arterial pressure was reduced to 53 ± 2 torr, and plasma renin activity increased to 8.8 ± 0.9 ng/ml/hr. Heart rate did not change. Discontinuation of sodium nitroprusside resulted in a gradual reduction of plasma renin activity to the awake level and a concurrent gradual increase in mean arterial pressure to its basal anesthetic value. When compared with previous work, these results indicate that propranolol attenuates nitroprusside-induced renin release, reduces the dosage of nitroprusside required to induce hypotension, suppresses reflex tachycardia, and prevents overshoot hypertension on discontinuation of nitroprusside.

Key Words: ANESTHETIC TECHNIQUES: hypotensive, nitroprusside • POLYPEPTIDES: renin-angiotensin • SYMPATHETIC NERVOUS SYSTEM: sympatholytic agents, propranolol.




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[Abstract] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1981 by the International Anesthesia Research Society.