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Anesth Analg 1981; 60:634-637
© 1981 International Anesthesia Research Society
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Respiratory Depression of Intravenous Hydroxyzine in Man

Potency, Duration, and Lack of Reversal by Naloxone

Margrit L. Gabathuler, MD*, and Robert D. Kaufman, MD{dagger}

* Research Fellow. Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024. {dagger} Assistant Professor. Department of Anesthesiology, UCLA School of Medicine, Los Angeles, California 90024.

Abstract

The effects of intravenous hydroxyzine and hydroxyzine with naloxone on respiration were determined in man. Drug effect was expressed as the shift in the 20-L intercept of the respiratory response curve measured by a rebreathing technique. The time-effect curve of hydroxyzine was found to be the same for hydroxyzine alone and in combination with naloxone, but significantly different from placebo or naloxone alone. The duration of respiratory depression in man resulting from hydroxyzine, 100 mg IV, is greater than 3 hours. Our data do not support the hypothesis that the respiratory depressant and recently discovered antinociceptive effects of hydroxyzine result from endorphin release or are mediated by opiate receptors.

Key Words: ATARACTICS: hydroxyzine • HYPNOTICS: hydroxyzine • ANTAGONISTS, Narcotic: naloxone






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1981 by the International Anesthesia Research Society.