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Anesth Analg 1981; 60:646-648
© 1981 International Anesthesia Research Society
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Cross-Mating of Mice Selectively Bred for Resistance or Susceptibility to Nitrous Oxide Anesthesia

Potencies of Nitrous Oxide in Offspring

Donald D. Koblin, PhD*, and Edmond I. Eger, II, MD{dagger}

* Assistant Research Chemist. Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143. {dagger} Professor of Anesthesia. Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143.

Abstract

To investigate the genetic bases of differences in nitrous oxide requirement in mice selectively bred for resistance (HI mice) or susceptibility (LO mice) to nitrous oxide anesthesia, the potency of nitrous oxide in offspring having one HI and one LO parent was measured. Nitrous oxide ED50s (±SD) in offspring having HI male and LO female parents or LO male and HI female parents were 1.53 ± 0.10 and 1.63 ± 0.14 atm, respectively. In contrast, the nitrous oxide ED50s for offspring having two LO parents was 1.26 ± 0.09 atm, and for offspring having two HI parents, 1.96 ± 0.10 atm. Thus, the nitrous oxide ED50s for offspring produced by cross-mating HI and LO animals approximated the average values for their parents. We conclude that no single gene determines dominance or recessiveness for nitrous oxide requirement in mice, and that the genetic control of resistance or susceptibility to nitrous oxide anesthesia probably involves many genes.

Key Words: ANESTHETICS, Gases: nitrous oxide • GENETIC FACTORS • POTENCY, Anesthetic: ED50, righting reflex




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1981 by the International Anesthesia Research Society.