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Anesth Analg 1983; 62:29-32
© 1983 International Anesthesia Research Society
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Plasma Binding of Pancuronium

Effects of Age, Sex, and Disease

Margaret Wood, MB, ChB, FFARCS, William J. Stone, MD, and Alastair J. J. Wood, MB, ChB, MRCP

Departments of Anesthesiology, Pharmacology, and Medicine, Vanderbilt University Medical School and Veterans Administration Medical Center, Nashville, Tennessee.

Abstract

The extent of pancuronium binding in plasma is controversial due to a lack of definitive studies in human plasma. The degree of pancuronium binding in human plasma and the concomitant effects of age, sex, and renal disease on drug binding were determined by equilibrium dialysis using [3H]pancuronium. The free fraction of pancuronium was 93.2 ± 1.6% in male subjects and 88.9 ± 2.5% in adult non-pregnant female subjects, indicating that pancuronium is not highly protein bound. The free fraction in newborns and their mothers was 91.0 ± 1.8% and 89 ± 13%, respectively. There were no significant differences between the plasma binding of pancuronium in men, nonpregnant women (whether on oral contraceptives or not), pregnant women, or neonates. The free fraction of pancuronium was unaltered (90.7 ± 2.1%) in patients with severe renal disease. We therefore conclude that the binding of pancuronium in human plasma is very low and that age, sex, oral contraceptives, pregnancy, and renal disease do not influence the plasma binding of this drug.

Key Words: NEUROMUSCULAR RELAXANTS: pancuronium • PROTEIN BINDING: pancuronium






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.