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Anesth Analg 1983; 62:870-874
© 1983 International Anesthesia Research Society
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Determinants of d-Tubocurarine Plasma Protein Binding in Health and Disease

Judy S. Walker DipPharm, (Nz), Colin A. Shanks, MD, and Kenneth F. Brown, PhD

Department of Pharmacy, University of Sydney, and the Department of Anaesthetics, Royal Prince Alfred Hospital, Camperdown, Australia.

Abstract

d-Tubocurarine protein binding was determined in plasma from normal surgical patients; patients with renal dysfunction; patients with alcoholic cirrhosis; and patients scheduled for coronary artery surgery and was compared with binding determined in solutions of isolated human serum albumin (HSA). The free fraction of d-tubocurarine was independent of plasma drug concentration throughout the range 0.1–3.0 µg/ml. The free fraction of d-tubocurarine in renal disease (0 44 ± 0.05), liver disease (0.53 ± 0.05), and cardiac disease (0.49 ± 0.05) was not significantly different from that in normal patients (0.50 ± 0.04). Furthermore, the free fraction of d-tubocurarine was unrelated to plasma concentrations of total protein, total globulin, albumin, total lipids, or {alpha}1-acid glycoprotein in the four patient groups. The free fraction of d-tubocurarine (0.55 ± 0.02, n = 7) in solutions of HSA (0.58 mM) was similar to that observed in plasma. Albumin, therefore, appears to be the major plasma binding protein for d-tubocurarine.

Key Words: NEUROMUSCULAR RELAXANTS: d-tubocurarine • PROTEIN BINDING: d-tubocurarine






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.