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Anesth Analg 1983; 62:885-888
© 1983 International Anesthesia Research Society
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Hemodynamic Responses to Physostigmine in Patients with a Drug Overdose

Eija Nilsson, MD, Olli A. Meretoja, MD, and Pertti Neuvonen, MD

Received from the Department of Anesthesia, Helsinki University Central Hospital; the Department of Anesthesiology, Children's Hospital of Helsinki; and the Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland.

Abstract

Hemodynamic responses to physostigmine were evaluated in eight patients with coma due to overdose with mainly anticholinergic drugs (AC) and in five patients with coma due to overdose with nonanticholinergic drugs (NAC). After correction of hypovolemia, but before administration of physostigmine, AC patients had significantly lower systemic vascular resistances, slightly higher cardiac outputs, and lower mean arterial pressures than NAC patients. Physostigmine produced negligible hemodynamic and, as expected, negligible neurological changes in NAC patients. In AC patients physostigmine produced, also as expected, improved consciousness and in addition significantly increased mean arterial pressure, cardiac output, and cardiac work without significantly affecting systemic vascular resistance.

Key Words: ANTAGONISTS, Miscellaneous: physostigmine






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.