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Anesth Analg 1983; 62:899-902
© 1983 International Anesthesia Research Society
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Anesthetic Potency of Dezocine and Its Interaction with Morphine in Rats

John C. Rowlingson, MD, Jeffrey C. Moscicki, MS, and Cosmo A. DiFazio, PhD, MD

Received from the Department of Anesthesiology, University of Virginia Medical Center, Charlottesville, Virginia 22908.

Abstract

A new partial agonist–antagonist analgesic drug, dezocine, was evaluated in rats for its anesthetic potency using a MAC-reduction model. Respiratory effects as shown by changes in PaCO2 were also analyzed. A reduction of approximately 50% in cyclopropane MAC was found with doses of 6 mg/kg or more. This is the largest reduction for any drug of this class. PaCO2 levels increased up to 52 mm Hg with doses of dezocine up to 2 mg/kg. No evidence of reversal of respiratory depression or of further respiratory depression was found with increasing dosages. Combining dezocine with morphine resulted in a further reduction in cyclopropane MAC without a significant change in PaCO2. This suggests that dezocine acts primarily on the same receptor (mu) as morphine and that this receptor activity is further modulated by effects of dezocine on a second opioid receptor.

Key Words: ANALGESICS: dezocine




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Discriminative Stimulus Effects of the Mixed-Opioid Agonist/Antagonist Dezocine: Cross-Substitution by Mu and Delta Opioid Agonists
J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1009 - 1017.
[Abstract] [Full Text]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.