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Anesth Analg 1983; 62:903-908
© 1983 International Anesthesia Research Society
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Hemodynamic Responses to Nifedipine in Dogs Anesthetized with Halothane

Steven R. Tosone, MD, J. G. Reves, MD, Igor Kissin, MD, PhD, L. R. Smith, MA, and S. E. Fournier

Received from the Department of Anesthesiology, The University of Alabama Medical Center, Birmingham, Alabama.

Abstract

The interaction of nifedipine and halothane was examined in 19 dogs. Nifedipine (10 µg/kg) was infused over 2 min in animals anesthetized with either 1% or 2% halothane. The predominant hemodynamic effect of nifedipine was a short-lived reduction (< 15 min) in mean blood pressure accompanied by a decrease in systemic vascular resistance. During 2% halothane anesthesia hypotension mean blood pressure was greater (P < 0.05) 15 and 30 min after nifedipine than during 1% halothane. Nifedipine hypotension was initially (2 min) associated with a 23% increase in heart rate and a 22% increase in cardiac output in animals anesthetized with 1% halothane, but during 2% halothane there was no change in heart rate. Changes in dP/dt and contractile force were minimal after nifedipine in both groups. The clinical implications of this study are that nifedipine given during halothane anesthesia may be associated with significant hypotension and that higher concentrations of halothane attenuate the reflex compensatory increase in heart rate. Doses of halothane and nifedipine must be chosen cautiously when the drugs are used together.

Key Words: HEART: nifedipine halothane • IONS: calcium blockers, nifedipine • ANESTHETICS, Volatile: halothane




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.