JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sheskey, M. C. Articles by Covino, B. G. Search for Related Content PubMed PubMed Citation Articles by Sheskey, M. C. Articles by Covino, B. G.

A Dose-Response Study of Bupivacaine for Spinal Anesthesia

Received from the Department of Anesthesia, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

Abstract

A randomized double-blind study was performed to elucidate the interrelationships among volume, concentration, and dosage of bupivacaine adminstered intrathecally. Sixty male patients between the ages of 40 and 80 years having transurethral surgery in the lithotomy position were studied using 10-, 15-, and 20-mg doses of glucose-free bupivacaine as either a 0.5 or a 0.75% solution. Success rate, time of onset and duration of anaglesia and motor block, and cardiovascular responses were assessed. It was found that both 15 and 20 mg of either concentration of bupivacaine provide satisfactory spinal anesthesia for transurethral urologic procedures. However, three of 20 patients receiving the 10-mg dose required supplementation with general anesthesia. Comparison of various volumes and concentrations of bupivacaine indicates that total dosage of bupivacaine is more important than volume or concentration. In several patients with sensory block involving cervical dermatomes, there was no significant hypotension or bradycardia, which suggests that cardiac output and venous return were maintained, perhaps because of the use of lithotomy position.

Key Words: ANESTHETIC TECHNIQUES: spinal • ANESTHETICS, Local: bupivacaine

This article has been cited by other articles:

				Y. T. Kawamata, K. Nishikawa, T. Kawamata, K. Omote, M. Igarashi, M. Yamauchi, K. Sato, M. Nakayama, and A. Namiki A Comparison of Hyperbaric 1% and 3% Solutions of Small-Dose Lidocaine in Spinal Anesthesia Anesth. Analg., March 1, 2003; 96(3): 881 - 884. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999