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Anesth Analg 1983; 62:1006-1009
© 1983 International Anesthesia Research Society
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Intracranial and Hemodynamic Changes after Succinylcholine Administration in Cats

James E. Cottrell, MD, John Hartung, PhD, Joseph P. Giffin, MD, and Barbara Shwiry, CRNA

Department of Anesthesiology, SUNY/Downstate Medical Center, Brooklyn, New York.

Abstract

Bolus injections of succinylcholine (1.5 mg/kg) significantly increased intracranial pressure (ICP) in cats under normal conditions from control levels of 8 ± 1 mm Hg to 16 ± 3 mm Hg (± SEM, P < 0.01), and in the presence of artificially increased ICP from control levels of 27 ± 1 mm Hg to 47 ± 4 mm Hg (P < 0.01). These approximately 100% increases in ICP were accompanied by a transitory decrease in mean arterial pressure (approximately 10 sec), followed by a 15–20% increase (P < 0.05). Pulmonary arterial pressure increased 20–30% (P < 0.05). These results, when considered in conjunction with results previously obtained in humans, suggest that succinylcholine may be contraindicated in neurosurgical patients.

Key Words: CEREBROSPINAL FLUID: pressure • NEUROMUSCULAR RELAXANTS: succinylcholine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.