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Anesth Analg 1983; 62:961-965
© 1983 International Anesthesia Research Society
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Inotropic and Anesthetic Potencies of Etomidate and Thiopental in Dogs

Igor Kissin, MD, PhD, Shigeru Motomura, MD, PhD, Donnie F. Aultman, BS, and J. G. Reves, MD

Department of Anesthesiology, School of Medicine, University of Alabama in Birmingham, Birmingham, Alabama 35294.

Abstract

The effects of etomidate and thiopental on myocardial contractility were compared in 10 experiments on isolated papillary muscle preparation perfused by a conscious donor dog. Equianesthetic doses of etomidate (1.4 mg/kg) and thiopental (15.5 mg/kg) were determined separately in conscious dogs. Tension developed by the papillary muscle decreased significantly less after etomidate (17 ± 2%) than after thiopental (33 ± 3%) (P < 0.002) when injected intravenously in equianesthetic doses in donor dogs. When added to arterial blood perfusing the papillary muscle, etomidate had 4–5 times more negative inotropic effect than thiopental. At the same time, the anesthetic potency of etomidate was approximately 11 times greater than that of thiopental. We conclude that both etomidate and thiopental produce a dose-dependent direct negative inotropic effect but that in equianesthetic doses, etomidate causes less pronounced depression of myocardial contractility than thiopental.

Key Words: ANESTHETICS, Intravenous: etomidate, thiopental • HEART: contractility




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.