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Anesth Analg 1983; 62:1065-1069
© 1983 International Anesthesia Research Society
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Variation in PCO2 between Arterial Blood and Peak Expired Gas during Anesthesia

Daniel B. Raemer, PhD, Deborah Francis, MD, FFARCS, James H. Philip, MD, and Ronald A. Gabel, MD

Received from the Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and the Department of Anesthesiology, University of Rochester Medical Center, Rochester, New York.

Abstract

Arterial PCO2 (PaCO2) can be continuously and noninvasively estimated by monitoring peak expired CO2 tension (PpeCO2). The practice of calibrating the estimate by an initial measurement of PaCO2 assumes that the difference in PCO2 tension between arterial blood and expired gas P(a-pe)co2 remains constant. We examined the stability of P(a-pe)CO2 during anesthesia in 15 patients undergoing major surgery. Mean P(a-pe)CO2 values ranged from 0.8–7.9 torr with maximum P(a-pe)CO2 values ranging from 4.5–13.0 ton. Calibration of P(a-pe)CO2 based on a single initial measurement of PaCO2 often over- or underestimated PaCO2. Mean estimated PaCO2 from calibrated P(a-pe)CO2 varied from - 7.9–6.4 torr with extreme estimates of — 12.8–12.3 torr. No consistent correlation was shown between P(a-pe)CO2 and duration of anesthesia, variations in ventilation, blood pressure, blood-gas tensions, PpeCO2 or temperature. We conclude that estimation of PaCO2 by monitoring PpeCO2 is not invariably reliable.

Key Words: CARBON DIOXIDE: tension • VENTILATION: carbon dioxide tension.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.