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Anesth Analg 1983; 62:1073-1077
© 1983 International Anesthesia Research Society
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Cognitive Reversal of Expected Nitrous Oxide Analgesia for Acute Pain

Samuel F. Dworkin, DDS, PhD, Andrew C. N. Chen, PhD, Linda LeResche, ScD, and Daniel W. Clark, BS

Received from the Departments of Oral Medicine and Psychiatry and Behavioral Sciences, and the Pain Center, University of Washington, Seattle, Washington.

Abstract

In a laboratory experiment, the expected analgesic action of 33% nitrous oxide was reversed by creating the expectancy of heightened awareness of bodily sensations. Pain threshold and tolerance of electrical tooth-pulp stimulation were significantly reduced. Results from a control study gave us a basis for comparison of changes in the verbal expression of pain when nitrous oxide was administered without introducing expectancies beyond those already held by the subjects. Contrasting results from the experimental and control studies confirm the powerful role of mental processes in mediating pain experience.

Key Words: PAIN, experimental • ANESTHETICS, Gases: nitrous oxide.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.