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Anesth Analg 1983; 62:151-154
© 1983 International Anesthesia Research Society
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MAC Values of Thiopental and Fentanyl in Rats

Koh Shingu, MD, Edmond I. Eger, II, MD, Brynte H. Johnson, AB, Francis W. Lurz, MA, and Robert F. Hickey, MD

Department of Anesthesia, University of California, Room HSE 1386, San Francisco, California 94143.

Abstract

A comparison of the effects of thiopental or fentanyl with those of inhaled anesthetics requires the establishment of a comparable level of anesthetic potency. Accordingly, using the response of male Sprague-Dawley rats to tail-clamping, we determined the ED50s for thiopental and fentanyl. Half of the rats were pretreated with phenobarbital. After subcutaneous injection of various doses of thiopental or fentanyl, each rat was tested for movement in response to tailclamping at 15-min intervals for 2 h. In untreated rats, the maximal effect of thiopental (i.e., the lowest ED50 value was 107 ± 10 mg/kg, mean ± SEM) occurred 75 min after injection. Although higher values were found at other times, differences from the nadir were relatively small. In rats pretreated with phenobarbital, the lowest value (130 ± 8 mg/kg) occurred at 60 min. The lowest ED50s for fentanyl (52 ± 7 µg/kg for control rats, and 73 ± 14 µg/kg for pretreated rats) were found at 15 min.

Key Words: ANESTHETICS, INTRAVENOUS: thiopental • NARCOTICS: fentanyl • POTENCY, ANESTHETIC: thiopental, fentanyl




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.