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Anesth Analg 1983; 62:207-210
© 1983 International Anesthesia Research Society
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Atracurium during Halothane Anesthesia in Humans

Joseph A. Stirt, MD, Anne L. Murray, MD, Ronald L. Katz, MD, Donna L. Schehl, RN, and Chingmuh Lee, MD

Department of Anesthesiology, UCLA School of Medicine, Los Angeles, CA 90024.

Abstract

The neuromuscular effects of atracurium were studied in 20 patients anesthetized with 0.8% end-tidal halothane. Neuromuscular blockade was monitored by recording the electromyographic activity of the adductor pollicis muscle resulting from stimulation of the ulnar nerve. Four groups of five patients received single atracurium doses of 0.1, 0.15, 0.2, or 0.4 mg/kg, respectively. The block produced by 0.1 mg/kg was 25–72% and lasted 6–21 min. The block produced by 0.15 mg/kg was 69–93% and lasted 16–32 min. The blocks produced by 0.2 and 0.4 mg/kg were 95% or greater and lasted 42–84 min and 55–104 min, respectively. When indicated, intubation was easily performed in all patients receiving 0.2 and 0.4 mg/kg. The block could be readily antagonized by neostigmine and atropine. Changes in heart rate and blood pressure following atracurium administration averaged less than 5%.

Key Words: NEUROMUSCULAR RELAXANTS: atracurium






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.