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Anesth Analg 1983; 62:317-323
© 1983 International Anesthesia Research Society
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Hemodynamic and Hepatic Effects of Methohexital Infusion during Nitrous Oxide Anesthesia in Humans

Cedric Prys--Roberts, DM, PhD FFARCS, John W. Sear, BSc, PhD MBBS, FFARCS, John M. Low, BM, BCh, FFARCS, Karen C. Phillips, MB, BCh, BAO, FF ARCS, and Jorge Dagnino, MD

Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol, United Kingdom.

Abstract

The hemodynamic effects of methohexital, at infusion rates of 60—65 and 120 µg/kg/min with concomitant inhalation of 67% nitrous oxide in oxygen, have been studied during spontaneous and controlled ventilation in 8 patients. Under most of the conditions studied methohexital infusion anesthesia was associated with lower arterial pressure (–13% to –33%) than in the awake state, decreased cardiac output (–26% to –38%), and increased systemic vascular resistance (+ 5% to +37%) during surgery, but also with decreased cardiac output (–25%) and decreased systemic vascular resistance (–13%) during anesthesia without surgery. The higher infusion rate was not associated with decreases in arterial pressure or cardiac output during either spontaneous or controlled ventilation. The hemodynamic response to laryngoscopy and intubation was poorly suppressed by methohexital in that peak arterial pressures exceeded the preanesthetic values by 33%. No evidence of impaired hepatocellular function was found after infusions of methohexital lasting up to 4 h.

Key Words: ANESTHETICS, Intravenous: methohexital • ANESTHESIA: cardiovascular • LIVER: hepatic function






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.