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Anesth Analg 1983; 62:324-326
© 1983 International Anesthesia Research Society
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Phosphorylase Ratio and Susceptibility to Malignant Hyperthermia

Celine A. Traynor, MB, Russell A. Van Dyke, PhD, and Gerald A. Gronert, MD

Department of Anesthesiology, Mayo Medical School, Rochester, MN 55905.

Abstract

The ratio of muscle phosphorylase a to total phosphorylase, expressed as a percent, was determined in vastus lateralis muscle of 26 patients to examine the efficacy of this parameter as a method for screening for susceptibility to malignant hyperthermia (MH). As standard screening, all patients also had muscle contracture responses determined to 2% halothane and 0.25—32 mM caffeine at 37°C. Each drug was given separately and not combined. Nine patients were susceptible to MH, based upon caffeine threshold of 2 mM or less (seven patients) or a rapidly developing contracturetension to halothane of more than 400 mg (seven patients, including five with positive caffeine responses). Mean phosphorylase ratio in these nine patients was 14.5 ± 2.0% (mean, SEM). In the 17 nonsusceptible patients mean phosphorylase ratio (12.4 ± 1.9%) was not significantly different. The range of phosphorylase ratios in susceptible patients was 6.5—26% while 13 nonsusceptible patients had ratios greater than 6% and up to 29%. The unacceptable high number of false-positive responses in nonsusceptible patients precludes the use of phosphorylase ratio as a definitive diagnostic test.

Key Words: HYPERTHERMIA: malignant • ENZYMES: phosphorylase • MUSCLE: skeletal






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.