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Anesth Analg 1983; 62:398-403
© 1983 International Anesthesia Research Society
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The Effect of Ketamine on Endotoxin-Induced Lung Injury

Balazs I. Bodai, MD, Bruce A. Harms, MD, Paul B. Nottingham, MD, Conrad Zaiss, BS, and Robert H. Demling, MD

Department of Surgery, University of California at Davis, Sacramento, and the Department of Surgery, University of Wisconsin, Madison.

Abstract

We investigated the effects of ketamine HCl on endotoxin-induced pulmonary injury in 20 chronically instrumented sheep with Sung lymph fistulas. The caudal mediastinal lymph node was cannulated in 20 ewes (45–55 kg). The catheter was externalized and the lymph allowed to drain freely. Pulmonary injury was induced by an intravenous infusion of Escherichia coli endotoxin (1.0–1.5 µ/kg body wt) over a 5-min period in 11 animals. The injury was characterized by an increase in pulmonary arterial pressure, pulmonary arterial wedge pressure, and lung lymph flow. There was no change in mean systemic arterial pressure. These changes were significantly attenuated by intravenous administration of ketamine HCl (5 mg/kg) following endotoxin injury in 9 other animals. When ketamine was given, the pulmonary arterial pressure decreased 32%, lung lymph flow decreased 27%, and systemic blood pressure increased 22%. Potential mechanisms for the hemodynamic effects of ketamine HCl in sepsis are discussed with particular reference to the pulmonary microvasculature.

Key Words: ANESTHETICS • Intravenous • ketamine • LUNG • edema




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.