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Anesth Analg 1983; 62:426-430
© 1983 International Anesthesia Research Society
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Fetal and Maternal Cardiovascular Effects of Atropine and Glycopyrrolate

Therese Abboud, MD, Julio Raya, MD, Shahpour Sadri, MD, Nicholas Grobler, MD, Lucille Stine, MD, and Frank Miller, MD

Departments of Anesthesiology and Obstetrics and Gynecology, Los Angeles County/University of Southern California Medical Center, Los Angeles, California. Presented at the Sixth European Congress of Anesthesiology, London, England, September, 1982.

Abstract

This study compared the effects of intravenous atropine and glycopyrrolate on maternal and fetal heart rates and variability, maternal blood pressure, and uterine activity in 20 normal full-term parturients in labor. Group 1 (N = 10) received 0.005 mg/kg of glycopyrrolate, and group 2 (N = 20) received 0.01 mg/kg of atropine. There were no statistically significant changes in fetal heart rates or variability in either group. Uterine activity increased in a normal manner as labor progressed. Maternal heart rate increased significantly and essentially equally in all patients in both groups ranging from 15 to 78 beats/min and a mean (± SD) of 36 ± 16 in group 1 and from 15 to 65 beats/min with a mean of 35 ± 17 in group 2. There were no statistically significant changes in maternal blood pressure in either group.

Key Words: PARASYMPATHETIC NERVOUS SYSTEM • atropine • glycopyrrolate • ANESTHESIA • obstetric




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.