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Anesth Analg 1983; 62:633-640
© 1983 International Anesthesia Research Society
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Ventilatory CO2 Sensitivity after Intravenous and Epidural Morphine in Volunteers

Enrico M. Camporesi, MD, Carl H. Nielsen, MD, Philip R. Bromage, MB, BS, FFARCS, and Philippe A. C. Durant, MD

Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.

Abstract

Ventilatory sensitivity to CO2 was measured at various times (0.5, 1, 3, 6, 10, 16, and 22 h) in 10 healthy young volunteers after 10 mg of morphine sulfate in 10 ml of saline injected intravenously (IVm) or by the epidural route (Em). The two randomized study sequences were completed 2–4 weeks apart. Ventilatory variables studied were resting endtidal CO2 (Petco2) measured before each rebreathing maneuver; slopes of the Ventilatory response curve (sVE) and position of the curve, calculated as the ventilation sustained for a fixed stimulus of Petco2 = 54 ton (VE54). Additionally, linear regressions were calculated for tidal volumes (VT) and respiratory rates (RR) during the rebreathing test, yielding sVT, VT54, sRR, and RR54. CO2-response curves were maximally depressed following IVm at the 0.5-h study period, while after Em, maximal respiratory depression was at the 6-and 10-h study period. Significantly greater depression after Em was demonstrated between 3 and 22 h by one or more of the following parameters: Petco2, sVE, VE54, VT54, and sRR. The results indicate substantial differences in magnitude, duration, and characteristics of the depression of the CO2 chemosensitivity between the two modes of administration of morphine, quite separate from the differences observed for serum morphine levels in these volunteers.

Key Words: ANALGESICS: morphine • ANESTHETIC TECHNIQUES: epidural morphine • VENTILATION: carbon dioxide response




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Can J Anesth, August 1, 2003; 50(7): 679 - 688.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.