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Anesth Analg 1983; 62:742-748
© 1983 International Anesthesia Research Society
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Cardiovascular Effects of Isoflurane-Induced Hypotension for Cerebral Aneurysm Surgery

Arthur M. Lam, MD, FRCP(C), and Adrian W. Gelb, MB, ChB, FRCP(C)

the Neuroanesthesia Division, Department of Anesthesia, University Hospital and University of Western Ontario, London, Ontario, Canada. Presented in part at the 56th Congress of the International Anesthesia Research Society, San Francisco, California.

Abstract

Deliberate hypotension was induced with isoflurane in 13 patients undergoing craniotomy for clipping of aneurysms. Cardiovascular function and gas exchange were monitored before, during, and after hypotension. In all cases, the desired level of hypotension [40 ± 1 (SEM) mm Hg] was achieved readily with prompt onset (5,7 ± 1.0 min) and recovery (6.3 ± 0.7 min). Cardiac output during hypotension (4.6 ± 0.3 L/min) was not significantly different from the control normotensive value (4.80 ± 0.3 L/min). Gas tensions during hypotension and during normotension were; Pao2 116 ± 6 and 111 ± 8 mm Hg; Paco2 33 ± 1 and 34 ± 1 mm Hg; respectively. No complication could be attributed to the use of isoflurane. We conclude that isoflurane can be employed safely and effectively as a hypotensive agent in neurosurgery.

Key Words: ANESTHETICS, Volatile: isoflurane • ANESTHETIC TECHNIQUES: hypotensive • ANESTHESIA: neurosurgical.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1983 by the International Anesthesia Research Society.