JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ogawa, S. Articles by Cairns, A. M. Search for Related Content PubMed PubMed Citation Articles by Ogawa, S. Articles by Cairns, A. M.

Differential Vulnerability of Large and Small Mammalian Myelinated Fibers to Glucose Lack

Recieve from the Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington.

Abstract

The excitability of A fibers of peripheral nerves in vitro is more susceptible to depression by energy lack than is excitability of C fibers. Whether there is also a differential vulnerability between small myelinated A fibers that conduct fast pain and large myelinated Aß fibers is unclear. We evaluated the relative abilities of Aß and A fibers to with stand energy lack in rabbit vagus nerve by measuring the amplitudes and latencies of the compound action potentials during incubation in glucose-free Ringer's-bicarbonate solution. We also evaluated the reversibility of the effects after returning the nerves to glucose containing solution. We found that A fibers are more susceptible to such energy lack and recover from it less completely than A fibers.

Key Words: METABOLISM—glucose • NERVE—differential sensitivity • PAIN—peripheral nervous system

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999