JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 1984; 63:31-34
© 1984 International Anesthesia Research Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vree, T. B.
Right arrow Articles by Arts, T. H. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vree, T. B.
Right arrow Articles by Arts, T. H. M.

Placental Transfer of Midazolam and Its Metabolite 1-Hydroxymethylmidazolam in the Pregnant Ewe

Tom B. Vree, PhD, Joke J. Reekers-Ketting, Robert J. Fragen, MD, PhD, and Theo H. M. Arts

Recieved from the Department of Anesthesiology and the Central Animal Laboratory, Sint Radboud Hospital, University of Nijmegen Medical School, Nijmegen, The Netherlands.

Abstract

Plasma concentrations of midazolam and its metabolites were measured in maternal and fetal blood after intravenous administration of 90 mg of midazolam to seven pregnant ewes in whom sampling catheters had been chronically implanted. Midazolam and its metabolite 1-hydroxymethylmidazolam crossed the placenta of the pregnant ewe. The fetal/maternal plasma concentration ratio of midazolam and the metabolite was 0.15. The distribution and elimination half-lives of midazolam and the metabolite were identical in both maternal and fetal circulations. The major compound found in the urine was the metabolite 1-hydroxymethylmidazolam glucuronide.

Key Words: HYPNOTICS, BENZODIAZEPINES—midazolam • ANESTHESIA—obstetrics




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Van de Velde, D. Van Schoubroeck, L. E. Lewi, M. A.E. Marcus, J. C. Jani, C. Missant, A. Teunkens, and J. A. Deprest
Remifentanil for Fetal Immobilization and Maternal Sedation During Fetoscopic Surgery: A Randomized, Double-Blind Comparison with Diazepam
Anesth. Analg., July 1, 2005; 101(1): 251 - 258.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.