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Anesth Analg 1984; 63:35-39
© 1984 International Anesthesia Research Society
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Potencies of Barbiturates in Mice Selectively Bred for Resistance or Susceptibility to Nitrous Oxide Anesthesia

Donald D. Koblin, PhD, MD, Francis W. Lurz, MA, Brian O'Connor, BS, Norman T. Nelson, PhD, Edmond I. Eger, II, MD, and Cedric R. Bainton, MD

Recieved from the Department of Anesthesia, University of California, San Francisco, and the Veterans Administration Medical Center, San Francisco, California.

Abstract

To test the possibility that mice selectively bred for resistance (HI mice) and susceptibility (LO mice) to nitrous oxide anesthesia have general differences in central nervous system sensitivity to other depressants, we examined the effects of four barbiturates in these two lines of mice. LO mice given intraperitoneal injections of barbital (275 mg/kg), hexobarbital (120 mg/kg), pentobarbital (65 mg/kg), or secobarbital (50 mg/kg) had significantly (16–46%) longer sleep times than HI mice. Concentrations of barbiturates were significantly (12–73%) greater in the serum and 3–55% greater in the brain on awakening in HI mice than in LO mice. The largest separations in potency between the HI and LO lines occurred with pentobarbital and hexobarbital and the smallest separations with barbital and secobarbital. We conclude that HI and LO mice do have a general resistance and susceptibility to barbiturates, but that the magnitude of the difference in central nervous system sensitivity between the two lines varies among barbiturates.

Key Words: ANESTHETICS, GASES—nitrous oxide • HYPNOTICS, BARBITURATES—barbital, hexobarbital, pentobarbital, secobarbital • GENETIC FACTORS.POTENCY—anesthetic






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.