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Effects of Fentanyl and Nitrous Oxide on Contractility of Blood-Perfused Papillary Muscle of the Dog

Recieved from the Department of Anesthesiology, University of Alabama School of Medicine, Birmingham, Alabama.

Abstract

The effects of fentanyl, nitrous oxide, and their combination on myocardial contractility were investigated in the papillary muscle preparation perfused by a donor dog. With a conscious donor, fentanyl infused directly into the arterial blood perfusing the papillary muscle produced a dose-related depression of developed tension. However, blood concentrations of fentanyl required to obtain the depression were in the range of 30–120 µg/ml. The ED₅₀ for fentanyl for suppression of papillary muscle contractility was 89 ± 9 µg/ml. When the donor dog was given nitrous oxide (N₂O,80% and O₂,20%), the developed tension of the papillary muscle decreased 25 ± 5%. Fentanyl administered during nitrous oxide anesthesia caused a decrease in developed tension that was not significantly different from that obtained without N₂O anesthesia (18 ± 4% vs 13 ± 4% for 30 µg/ml, and 61 ± 5% vs 58 ± 4% for 100 µg/ml). The results suggest that fentanyl produces a direct negative inotropic effect only in concentrations that are 2–3 orders of magnitude higher than its blood concentrations in fentanyl-induced anesthesia. When fentanyl and nitrous oxide are used together their interaction is not significantly different from additive.

Key Words: ANESTHESIA, intravenous—fentanyl • ANESTHETICS, gases—nitrous oxide • HEART—contractility

This article has been cited by other articles:

				J. D. Swenson and P. L. Bailey Opioids in Cardiovascular Anesthesia Seminars in Cardiothoracic and Vascular Anesthesia, July 1, 1997; 1(2): 146 - 163. [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999