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Anesth Analg 1984; 63:900-902
© 1984 International Anesthesia Research Society
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Antagonism of Diazepam by Aminophylline in Healthy Volunteers

Bernhardt H. Meyer, MMED(ANES), FFA(SA), Otto F. Weis, MMED(ANES), FFA(SA), and Frank O. Mµller, MBChB

Department of Pharmacology, University of the Orange Free State, Bloemfontein, Republic of South Africa.

Abstract

Six healthy volunteers participated in a randomized, double-blind cross-over study of the effects of intravenous aminophylline on diazepam-induced sedation. Each subject participated in two phases and in each phase received either diazepam (15 mg intravenously) followed by placebo or di-azepam followed by aminophylline (2 mg/kg intravenously). Critical flicker fusion times and reaction times were measured sequentially as indices of vigilance. Subjects also assessed their own vigilance on a visual analogue scale. Aminophylline given after diazepam significantly improved vigilance as measured by the visual analogue scale from 60 to 150 min after administration of diazepam, while total reaction time was significantly improved at 90, 210, and 270 min. There was no significant correlation between the-ophylline plasma levels and its effects on vigilance.

Key Words: PHARMOCOLOGY—aminophylline • HYPONOTICS BENZODIAZEPINES-diazepam




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[Abstract] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.