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Anesth Analg 1984; 63:911-914
© 1984 International Anesthesia Research Society
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Hematocrit and the Solubility of Volatile Anesthetics in Blood

Jerrold Lerman, MD, FRCP(C), George A. Gregory, MD, and Edmond I. Eger, II, MD

Departments of Anesthesia and Pediatrics, and the Cardiovascular Research Institute, University of California, San Francisco.

Abstract

To clarify the effect of hematocrit on the solubility of volatile anesthetics in blood, we measured the blood-gas partition coefficients of isoflurane, enflurane, halothane, and methoxyflurane concurrently at 37°C in blood from four adults. We measured the blood-gas partition coefficients in the plasma (hematocrit 0%) and packed red cell fractions (hematocrit 80%), and in four mixtures of these two fractions (hema-tocrits 10%, 25%, 40%, and 55%). The mixtures were prepared by recombining appropriate amounts of plasma and packed red cells from each adult. As hematocrit increased, the blood-gas partition coefficient of isoflurane decreased linearly (P < 0.01), whereas that of enflurane increased linearly (P < 0.05). The partition coefficient for isoflurane in plasma was 20% greater than that in packed red cells, whereas the partition coefficient for enflurane in plasma was 10% less than that in packed cells. The blood-gas partition coefficients of halothane and methoxyflurane did not change significantly between measurements in plasma and packed red cells. We conclude that hematocrit exerts a statistically significant effect on the blood-gas partition coefficient of isoflurane and enflurane.

Key Words: ANESTHETICS VOLATILE-enflurane, halothane, isoflurane, methoxyflurane • SOLUBILITY—blood • BLOOD—hematocrit




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.