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Anesth Analg 1984; 63:1017-1020
© 1984 International Anesthesia Research Society
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Caudal Anesthesia with Lidocaine or Bupivacaine

Plasma Local Anesthetic Concentration and Extent of Sensory Spread in Old and Young Patients

Peter R. Freund, MD, T. Andrew Bowdle, MD, PhD, John T. Slattery, PhD, and Larry E. Bell, MD

Departments of Anesthesiology, Physiology and Biophysics, and Pharmaceutics, University of Washington School of Medicine, Seattle, Washington; and Veterans Administration Medical Center, Seattle, Washington.

Abstract

Continuous caudal peridural anesthesia with 2% lidocaine (6 mg/kg) or 0.75% bupivacaine (2.2 mg/kg), both with epinephrine 1:200,000, was studied in two groups of male patients, younger than 40 or older than 55 yr old, respectively. Patients receiving lidocaine in the younger group (n = 6) were 32 ± 5.2 (mean ± SD) yr old and weighed 75 ± 12 kg, while those in the older group (n = 16) were 66 ± 5.3 yr old and weighed 72 ± 8.2 kg. Patients receiving bupivacaine in the respective groups were 27 ± 7.0 yr old (n = 5), and 76 ± 10 kg compared to 69 ± 10 yr (n = 14) and 75 ± 10 kg. Anesthesia was satisfactory in all patients. Extent of sensory anesthesia, peak plasma lidocaine or bupivacaine concentrations, and area under the plasma concentration-time curves were independent of age. No local anesthetic toxicity was observed and peak drug concentrations were below those commonly associated with toxicity.

Key Words: ANESTHETIC TECHNIQUES—caudal, epidural • ANESTHETICS, LOCAL—lidocaine, bupivacaine






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.