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Anesth Analg 1984; 63:1059-1064
© 1984 International Anesthesia Research Society
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Evidence that Halothane Inhibits Norepinephrine Release from Sympathetic Nerve Endings in Dog Saphenous Vein by Stimulation of Presynaptic Inhibitory Muscarinic Receptors

Duane K. Rorie, MD, PhD, Gertrude M. Tyce, PhD, and Ronald A. Mackenzie, DO

Departments of Anesthesiology, Physiology, and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota.

Abstract

Studies were done to determine the mechanism whereby halothane inhibits the release of norepinephrine from postganglionic sympathetic nerve endings. Helical strips of dog saphenous vein were mounted for superfusion and measurement of isometric contractile tension in the presence or absence of halothane (1.2 or 2.5%). Endogenous norepinephrine overflowing in response to electrical stimulation (10 V, 2 Hz for 15 min), and the content of norepinephrine remaining in the veins after stimulation, were measured by liquid chromatography with electrochemical detection. The data indicate that halothane decreased the stimulation-evoked release of norepinephrine by stimulation of prejunctional inhibitory muscarinic receptors. Evidence was also obtained that halothane may impair clearance of norepinephrine from the synaptic cleft.

Key Words: ANESTHETICS, VOLATILE—halothane • MEASUREMENT TECHNIQUES—chromatography, column, liquid, electrochemical detection • RECEPTORS—presynaptic muscarinic • SYMPATHETIC NERVOUS SYSTEM—adrenergic nerve ending




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.