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Anesth Analg 1984; 63:1116-1120
© 1984 International Anesthesia Research Society
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Clinical Comparison of Midazolam Hydrochloride and Midazolam Maleate for Anesthesia Induction

Benjamin B. Blackmon, MD, John E. Mahaffey, MD, and J. David Baker, III, MD

Department of Anesthesiology, Medical University of South Carolina, Charleston, South Carolina.

Abstract

The current study was undertaken to determine whether the same doses (mg/kg) of 5 mg/ml of midazolam hydrochloride and 2.5 mg/ml of midazolam maleate are required for the induction of anesthesia. Midazolam hydrochloride and midazolam maleate were compared in a prospective double-blind fashion, in which both cardiopulmonary and sedative effects were measured in 12 patients who required repeated anesthesia for serial gynecologic radium insertions. The results showed no significant differences in clinical activity between midazolam maleate and the newer preparation, midazolam hydrochloride. Time of onset, recovery time, lack of venous irritation, and stability of cardiopulmonary variables when using the hydrochloride were essentially the same with the maleate.

Key Words: ANESTHETICS—intravenous • HYPNOTICS, BENZODIAZEPINES—midazolam • INDUCTION—anesthesia






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.