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Anesth Analg 1984; 63:437-440
© 1984 International Anesthesia Research Society
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Time Course of Muscle Relaxation with a Combination of Pancuronium and Tubocurarine

Rajinder K. Mirakhur, MD, Sujit K. Pandit, MD, Christopher J. Ferres, FFARCS, and Fiona M. Gibson, FFARCS

The Departments of Anaesthetics, Royal Victoria Hospital, Belfast, and The Queen's University of Belfast, Belfast, Northern Ireland.

Abstract

A combination of pancuronium and d-tubocurarine is associated with potentiation of the neuromuscular blocking effects of each drug used singly. The time to onset of maximum block and the time to 25% recovery after administration of equipotent (ED95) doses of pancuronium (0.07 mg/kg) alone, d-tubocurarine (0.51 mg/kg) alone, and pancuronium (0.024 mg/kg) in combination with d-tubocurarine (0.144 mg/kg) were studied in three groups of 10 patients each. The time to onset of maximum block urns slightly but not significantly shorter with the combination (3.5 min) than with pancuronium (4.78 min) or d-tubocurarine (4.88 min). The time to 25% recovery with the pancuronium-d-tubocurarine combination (39.7 min) was significantly shorter than it was after d-tubocurarine (57.6 min) but not significantly different from pancuronium (54.4 min). The combination of pancuronium and d-tubocurarine also was associated with greater cardiovascular stability.

Key Words: NEUROMUSCULAR RELAXANTS—pancuronium, d-tubocurarine. • INTERACTIONS (DRUG).






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1984 by the International Anesthesia Research Society.