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Anesth Analg 1985; 64:1060-1064
© 1985 International Anesthesia Research Society
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Electrophysiologic Effects of Enflurane and Halothane on Isolated Rabbit Hearts in the Presence and Absence of Metabolic Acidosis

Suzuko Ozaki, MD, Yasuyuki Gotoh, MD, Haruaki Nakaya, MD, Mitsue Azuma, Mphar, and Morio Kanno, MD

Departments of Anesthesiology and Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan

Abstract

Electrophysiologic effects of halothane and enflurane in the presence of a normal pH and during metabolic acidosis were examined in isolated rabbit hearts perfused at a constant rate. During exposure to a normal pH, both halothane and enflurane produced concentration-dependent suppression of sinus node automaticity and atrioventricular conduction. Intraatrial and intraventricular conduction times during constant pacing were slightly but significantly prolonged by these anesthetics at 2 MAC. The magnitudes of these electrophysiologic changes were similar with halothane and enflurane when compared at the same MAC. These electro-physiologic effects became more marked during metabolic acidosis (pH 6.9). These results suggest that enflurane and halothane have direct depressant actions on the cardiac conduction system and that these electrophysiologic effects may be augmented by metabolic acidosis.

Key Words: ANESTHETICS, VOLATILE—halothane, enflurane • HEART, conduction systems






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.