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Anesth Analg 1985; 64:667-671
© 1985 International Anesthesia Research Society
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Direct Opioid Application to Peripheral Nerves Does Not Alter Compound Action Potentials

Osafumi Yuge, MD, PhD, Maki Matsumoto, MD, Luke M. Kitahata, MD, PhD, J. G. Collins, PhD, and Mesaki Senami, MD

Received from the Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut.

Abstract

The identification of opiate receptors on primary afferent fibers near the dorsal root ganglia suggests that opiates may be able to affect conduction in primary afferent nerve fibers. We examined the effect of directly applied, preservative-free morphine sulfate (0.1 mg/kg) and fentanyl citrate (25 µg/kg) on the A beta, A delta, and C components of the compound action potential of the superficial radial nerve in decerebrate cats (n = 18). Neither drug caused any significant change in the area under the curve of any of the compound action potentials studied. These data indicate that systemically administered opiates are unlikely to cause changes in primary afferent nerve conduction.

Key Words: ANALGESICS—MORPHINE, fentanyl




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.