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Effects of Halothane and Fentanyl Anesthesia on Plasma ß-Endorphin Immunoreactivity during Cardiac Surgery

Received from the Department of Anesthesiology, University of Arizona Health Sciences Center, Tucson, Arizona.

Abstract

We studied the effects of halothane anesthesia (n = 6) and fentanyl anesthesia (n = 9; 50–100 µg/kg) on plasma ß-endorphin immunoreactivity as a measure of stress response during coronary artery bypass grafting, including cardiopulmonary bypass. Plasma levels of ß-endorphin immunoreactivity measured prior to induction, after induction, after intubation, after skin incision, during cardiopulmonary bypass, and on leaving the operating room were significantly higher in patients given halothane during cardiopulmonary bypass and on leaving the operating room than they Were in patients given fentanyl.

Key Words: ANESTHESIA, cardiac • ANESTHETICS, VOLATILE—halothane • ANESTHETICS, INTRAVENOUS—fentanyl • PEPTIDES—ß-endorphin

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999