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Anesth Analg 1985; 64:777-780
© 1985 International Anesthesia Research Society
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Atracurium—Receptor Kinetics

Simple Behavior from a Mixture

Yoshikiyo Amaki, MD, Barbara E. Waud, MD, and Douglas R. Waud, MD, DPHIL

The Departments of Anesthesiology and Pharmacology, University of Massachusetts Medical Center, Worcester, Massachusetts.

Abstract

The apparent atracurium-receptor dissociation constant was assayed at the end-plate region of isolated guinea pig muscles. In a parallel series of experiments, the ED50 for producing neuromuscular block in the lumbrical muscle was also determined. The ratio of these two values was similar to the ratio found with classical competitive neuromuscular blocking agents like d-tubocurarine or pancuronium. We conclude that the commercial preparation of atracurium, though a mixture containing isomers of different configurations, behaves kinetically in a manner indistinguishable from what would be expected from a single substance

Key Words: NEUROMUSCULAR RELAXANTS—atracurium.




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[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.