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Anesth Analg 1985; 64:781-785
© 1985 International Anesthesia Research Society
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Electrophysiologic Evidence for Involvement of the Pituitary Region in Opiate Analgesia

Ad Trouwborst, MD, PhD, Wilhelm Erdmann, MD, PhD, Hisashi Yanagida, MD, PhD, and Guenter Corssen, MD, PhD

The Department of Anesthesia, Erasmus University Rotterdam, The Netherlands; the Department of Anesthesia and Pain Clinic, Tokyo Kosei Nenkin Hospital, Tokyo, Japan; and Maricopy County Hospital, Phoenix, Arizona.

Abstract

In the past, various reports have discussed the relationship between the pituitary and analgesia. The purpose of the present study was to explore the possible role of the pituitary region in the mediation of pain by opioids. Tooth pulp evoked potentials recorded from primary somatosensory cortex and from the pituitary region of rabbits were recorded before and after an injection of opiates. Tooth pulp evoked potentials recorded from the primary somatosensory cortex were markedly inhibited after admission of fentanyl, while the tooth pulp evoked potentials recorded from the pituitary region were facilitated. It is concluded that the pituitary region plays a role in the mediation of pain and that this area is involved in the mechanism of opiate analgesia

Key Words: ANALGESICS—fentanyl. • BRAIN—pituitary.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.