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Anesth Analg 1985; 64:801-806
© 1985 International Anesthesia Research Society
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Potentiation of Systemic Morphine Analgesia in Humans by Proglumide, a Cholecystokinin Antagonist

D. D. Price, PhD, A. von der Gruen, MD, J. Miller, BS, A. Rafii, MD, and C. Price, BS

The Pain Management Clinic, Department of Anesthesiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia.

Abstract

Proglumide, a cholecystokinin antagonist, potentiates analgesia produced in rats by morphine and endogenous opiates, and appears to reverse tolerance in rats to opiate analgesia. Therefore, proglumide and other cholecystokinin antagonists may be clinically valuable. We have tested pro-glumide's possible opiate analgesic potentiating effects by examining, in volunteers, the effects of morphine and proglumide on human pain visual analogue scale responses to 45–51°C skin temperature stimuli. Proglumide (50–100 µg intravenously) potentiated both the magnitude and duration of analgesia produced by small doses of morphine. This study provides indirect evidence for a cholecystokinin-opiate interaction in humans. Therefore, cholecystokinin antagonists such as proglumide may serve to potentiate exogenous or endogenous opiate action

Key Words: ANTAGONISTS, miscellaneous—proglumide.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.