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Anesth Analg 1985; 64:864-866
© 1985 International Anesthesia Research Society
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Response Differences of Paretic and Healthy Extremities to Pancuronium and Neostigmine in Hemiplegic Patients

Hiroshi Iwasaki, MD, Akiyoshi Namiki, MD, Keiichi Omote, MD, Tetsuo Omote, MD, and Takeo Takahashi, MD

Department of Anesthesiology, Sapporo Medical College and Hospital, Chuoku, Sapporo, Japan.

Abstract

The purpose of this study was to examine differences in train-of-four (TOF) ratios between paretic and healthy extremities after pancuronium and neostigmine administration in 31 patients with hemiparesis. The TOF ratios on the paretic side after pancuronium administration were greater than those on the healthy side in all patients. Patients were classified according to the size of the difference in the TOF ratio on both sides. In group I, differences in TOF ratios were greater than 20%, and in group 2, they were less than 20%. Fifteen of 17 patients in group 1 had hemiparesis for over three weeks, and in group 2, 10 of 14 patients had hemiparesis for less than three weeks. Patients with flaccid hemiparesis were distributed equally in both groups, while all patients with spastic hemiparesis belonged to group 1. The difference in increase in TOF ratios after neostigmine was the same as the difference in decrease produced by pancuronium.

Key Words: NEUROMUSCULAR RELAXANTS—pancuronium • COMPLICATIONS—paraplegia






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.