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Anesth Analg 1986; 65:9-14
© 1986 International Anesthesia Research Society
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Ventilatory and Circulatory Responses to Carbon Dioxide and High Level Sympathectomy Induced by Epidural Blockade in Awake Humans

Shuji Dohi, MD, Reiko Takeshima, MD, and Hiroshi Naito, MD

Received from the Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, and the Department of Anesthesiology, The University of Tsukuba Hospital, Sakuramura, Japan.

Abstract

In order to examine the effects of cervico-thoracic epidural block with 1.5% lidocaine on Ventilatory and circulatory responses to carbon dioxide, the authors studied the CO2-ventilatory response curves and the changes in heart rate (HR) and blood pressure (AP) to rebreathing of exhaled gas before and after the block in healthy volunteers. Neither resting ventilation nor ventilatory response to CO2 was affected by the epidural block (mean analgesic level extended from C4 to T7); the slope of the CO2-ventilatory response curve averaged 2.38 ± 0.81 L·min-1·mm Hg-1 (mean ± SD) before and 2.32 ± 0.82 L·min-1·mm Hg-1 after the block. Resting HR and AP decreased significantly (P < 0.01) after the block, but responses in HR and AP to CO2 rebreathing were not significantly changed by the block. Plasma concentrations of norepinephrine and epinephrine were similar before and after the block both with and without CO2 rebreathing. These results indicate that high levels of sympathetic denervation induced by epidural block do not impair circulatory and ventilatory responses to carbon dioxide in awake, healthy humans.

Key Words: VENTILATION—carbon dioxide response • CARBON DIOXIDE—hypercarbia • ANESTHETIC TECHNIQUES, EPIDURAL




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.