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Anesth Analg 1986; 65:1149-1154
© 1986 International Anesthesia Research Society
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Morphine and Fentanyl Interactions with Thiopental in Relation to Movement Response to Noxious Stimulation

Igor Kissin, MD, PhD, John O. Mason, III, BS, and Edwin L. Bradley, Jr, PhD

Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Abstract

The effects of morphine-thiopetztal and fentanyl-thiopental combinations on the movement response caused by tail clamping a w e studied in rats. Doses that prevented movement response when the agents were given singly and when the agents were given in combination were determined by a probit procedure and compared with isobolgyraphic analysis. With doses of the above agents sufficient to block the movement response to fail clamping (ED50 values: 4.7 (3.3–6.6) mg/kg intravenously for morphine; 8.3 (5.8–11.3) µg/kg intavenously for fentanyl; and 18.8 (17.9–19.7) mg/kg intravenously for thiopental) both fentanyl and, to a lesser extent, morphine have a less than additive or an antagonistic interaction with thiopental. This antagonism is a relative one that does not increase the requirement for one agent upon the addition of another agent.

Key Words: ANESTHETICS, INTRAVENOUS—thiopental • ANALGESICS—morphine, fentanyl • INTERACTIONS (DRUGS)




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[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.