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Anesth Analg 1986; 65:1170-1174
© 1986 International Anesthesia Research Society
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The In Vitro and In Vivo Effects of Isoflurane and Nitrous Oxide on Platelet Aggregation

Brent G. Fauss, MD, James C. Meadows, MD, Christine Y. Bruni, BS, and G. D. Qureshi, MD

Departments of Anesthesia, Pathology, and Medicine, Medical College of Virginia, Richmond, Virginia.

Abstract

In view of the possible antiaggregration effects of newer general anesthetics we investigated the in vitro and in vivo effects of isoflurane and nitrous oxide on platelet aggregation. Platelets obtained from 18 healthy volunteers, were exposed in vitro for 30 min in a closed chamber to oxygen-carbon dioxide (90%,5%) (control), oxygen-carbondioxide-nitrous oxide (80%), or oxygen-carbondioxide-isoflurane (1.5%) with or without nitrous oxide (80%). Samples were tested in ADP- and collagen-induced aggregation tests. Both nitrous oxide and isoflurane produced statistically significant inhibition of ADP-induced aggregation. Inhibition of collagen-induced aggregation was not statistically significant. In 18 patients who received nitrous oxide (3 L/min) and isoflurane (1–2%) during anesthesia, platelet aggregation was reduced significantly. We conclude that both nitrous oxide and isoflurane cause moderate but statistically significant inhibition of platelet aggregation that may be clinically important in some patients.

Key Words: BLOOD—platelets • ANESTHETICS, VOLATILE—isoflurane • ANESTHETICS, GASES—nitrous oxide




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.