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Anesth Analg 1986; 65:1186-1188
© 1986 International Anesthesia Research Society
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Effect of Short-term Smoking Halt on Carboxyhemoglobin Levels and P50 Values

J. Reddy Kambam, MD, Lily H. Chen, MD, and Steve A. Hyman, MD

Department of Anesthesiology Vanderbilt University Medical Center, Nashville, Tennessee.

Abstract

Fifteen informed volunteers who smoked one to two packs of cigarettes per day were studied to measure changes in carboxyhemoglobin levels and P50 after smoking was stopped for 12 hr. Before smoking was stopped, carboxyhemoglobin levels (6.55 ± 0.40%) were above normal, and the P50 (22.92 ± 0.25 mm Hg) was significantly shifted to the left. After smoking was stopped for 12 hr there was a significant decrease in carboxyhemoglobin levels to 1.06 ± 0.16% (P < 0.001), and P50 shifted towards normal to 26.41 ± 0.14 mm Hg (P < 0.001). The authors conclude that within even as little as 12 hr after cessation of smoking, carboxyhemoglobin and P50 levels change towards normal values.

Key Words: OXYGEN, OXYHEMOGLOBIN DISSOCIATION—P50 • BLOOD, HEMOGLOBIN—Oxygenation • COMPLICATIONS—smoking




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.